Genome-Scale Closure

Instrument-Day Throughput Closes

runs to target

Project scale is repeated physical readout with an exact day ledger. Exact arithmetic here means exact results for the stated model inputs; measured inputs still carry uncertainty and significant-figure limits.

highlighted = computed this step

A run is lanes times reads times length

There are 4 lanes, 5 reads per lane, and 100 bases per read, so one run has 2000 bases.

Brun=4⋅5⋅100=2000B_{\text{run}}=4\cdot5\cdot100=2000
Indexed throughputIndexed measurements become exact count budgets.run outputday outputindexed readout

Instrument-days scale the run output

With 2 instruments and 3 runs per day, the output is 12000 bases per day. A 24000 base target takes 2 days.

Bday=2⋅3⋅2000=12000,D=2B_{\text{day}}=2\cdot3\cdot2000=12000,\quad D=2
Indexed throughputIndexed measurements become exact count budgets.run outputday outputindexed readout