Genome-Scale Closure

Coverage Addresses Join

reads and chip slots

Genome evidence needs both coverage arithmetic and physical addresses. Exact arithmetic here means exact results for the stated model inputs; measured inputs still carry uncertainty and significant-figure limits.

highlighted = computed this step

Coverage is reads times length over genome size

The training read budget is 30 reads of 100 bases over a 1000 base genome, so coverage is 3.

C=30⋅100/1000=3C=30\cdot100/1000=3
Genome measurement pipelineCoverage and chip addresses are checked from the same exact inputs.coveragepipeline

The physical chip still needs addresses

The chip side has 5 rows by 4 columns, so it has 20 physical addresses.

Naddr=5⋅4=20N_{\text{addr}}=5\cdot4=20
Genome measurement pipelineCoverage and chip addresses are checked from the same exact inputs.coveragepipeline