Boolean networks are qualitative hypotheses, and synchronous update is a modelling choice.
highlighted = computed this step
Boolean models are qualitative
A Boolean model keeps only ON and OFF. It leaves out expression levels, rates, and delays, so it is a qualitative hypothesis about regulatory logic rather than a quantitative model.
ON/OFF logic=expression level
Synchronous update is a modelling choice
Updating all genes at once is an idealization. The toggle's 00 to 11 oscillation is a synchronous artifact: a real toggle switch is bistable, with stable memory states 01 and 10. Asynchronous dynamics can give different attractors.