Reads Become Genome-Scale Evidence

Human Genome Project Scale

repeated indexed measurements

A toy genome-project pipeline combines coverage and chip address counts. Exact arithmetic here means exact results for the stated model inputs; measured inputs still carry uncertainty and significant-figure limits.

highlighted = computed this step

The pipeline still starts with coverage

Thirty reads of one hundred bases over a one thousand base toy genome gives coverage 3 times.

c=30⋅1001000=3c=\frac{30\cdot100}{1000}=3
Genome measurement pipelineCoverage and chip addresses are checked from the same exact inputs.coveragepipeline

Parallel slots are a separate count

The chip side has 20 address slots. Genome projects scale by repeated indexed physical measurements, not by one magic read.

Nslots=5⋅4=20N_{\text{slots}}=5\cdot4=20
Genome measurement pipelineCoverage and chip addresses are checked from the same exact inputs.coveragepipeline